Strategic Life Science

Life Science

Under cellular technology-based services, provide including cellular drugs R&D, large molecule drugs R&D, clinical research services and R&D and sales on self-owned skincare brand.

Cellular Drugs R&D

Mainly target on hospitals, cell drug development enterprises, and health and beauty institutions, providing research and preparation services for clinical therapeutic-grade cells and their derivatives.

Research and clinical-grade stem cells

Examples of current collaborations with hospitals

1. Treating dry eye syndrome with stem cells

2. Treating psoriasis with stem cells

3. Treating pulmonary fibrosis with stem cells

4. Treating diabetic foot with stem cells

Research cell application clients:

1

Major top hospitals nationwide.
2

Some research institutions.
3
Pharmaceutical companies.
4

Universities.

Clinical cell application clients:

1
Top hospitals in the East China region.
2
Pharmaceutical companies.

Exosomes from Stem Cells (Raw Material)

Exosomes are tiny vesicles secreted by stem cells into particle sizes range from 30-150nm containing proteins, nucleic acids, lipids, polysaccharides and other substances in cells

Function for intercellular communication, that can be secreted and ingested by different cell types, facilitate material exchage and signal communication between cells involved in immune response, antigen presentation and cell differentiation

Large Molecule Drugs R&D

Utilizing the characteristic that GP96, a heat shock protein, is not expressed on the surface of normal cells but is highly expressed on the membrane surface of most (about 70%) tumor tissues (breast cancer, liver cancer, etc.), GP96 is being used as a new target for treating breast cancer and other solid tumors. Research and transformation of targeted membrane GP96 macromolecular drugs are being carried out.

Clinical Research Services

The customers are mostly from hospitals, universities, and pharmaceutical companies, providing them with basic research and drug development services centered on animal experiments.

Laboratory with the Third People's Hospital of Hangzhou

Joint Laboratory of School of Life Science and Health Engineering, Jiangnan University

Cellular Base for Science Popularization Education, Zhejiang Association for Science and Technology

Postdoctoral Workstation of School of Chemistry, Fudan University

Assessment Platform for Cell Function

The cell function evaluation platform focuses on the following four areas:

1

Clinical-grade application cells
2

Traditional cell lines
3

Primary cells
4

Cell functions mediated by biomaterials

The purpose is to study the state and function of cells under different intervention systems. These include:

1
Cell proliferation, toxicity detection
2

Cell mobility function detection
3

Cell death, apoptosis
4

Cell differentiation
5

Wound healing

SPF-graded Preclinical Animal Lab

The animal facilities of the Small Animal Lab have the SPF-graded shelter environment. The area of the shelter environment is 980 sqm, with 11 mouse breeding rooms and 2 independent facility rooms. The Functional Lab can conduct pharmacology, pharmacodynamics, pharmacokinetics experiments on 10,000 mice and 5,000 rats at the same. The operation system has passed ISO9001 quality management system certification and is carried out strictly in accordance with AAALAC guidelines.

The services currently provided include:

Pharmacological experiments on animal disease models
Small animal imaging analysis
Pharmacokinetics/Toxicokinetics experiments
In vivo tracing of cell drugs
Animal imaging analysis

Animal Model

The Group possesses mature modelling technologies for respiratory system, cardiovascular system, digestive system, and tumor disease models, covering up to 300 types of animal disease models. Therefore, we have the capability to complete preclinical research.

Cardiovascular System

Myocardial infarction in rats/mice
Chronic heart failure in rats/mice
Myocardial fibrosis in rats/mice
Cerebral infarction model in rats/mice
Myocardial ischemia-reperfusion in rats
Arteriosclerosis in mice

Respiratory System

Asthma in rats/mice
Pulmonary hypertension in rats/mice
Acute lung injury in rats/mice
Chronic bronchitis in rats/mice
Pulmonary emphysema in rats
Acute respiratory distress in mice
Pulmonary fibrosis in mice

Digestive System

Liver fibrosis in rats/mice
Fatty liver in rats/mice
Cirrhosis in rats/mice
Acute enteritis in rats/mice
Ulcerative colitis in rats/mice
Intestinal fibrosis in rats/mice
Pancreatitis in rats/mice
Intestinal ischemia-reperfusion in rats/mice
Gastritis in rats/mice
Gastric ulcer in rats/mice
Reflux esophagitis in rats

Otolaryngology

Periodontitis in rats/mice
Oral ulcers in rats/mice
Rhinitis in rats/mice

Tumor Types

Subcutaneous Tumor
Induced In Situ Tumor
Transplanted In Situ Tumor
70 Hepatocellular Carcinoma PDX model

Self-Owned Skincare Brand (R&D And Sales）

The Group has developed its own core raw materials and created its own science and technology skincare brand , and has now formed a full ecological product system of social e-commerce, life beauty, medical beauty, and live streaming e-commerce.